USP <788> Particulate Matter Injections

Ensuring patient safety is paramount in the pharmaceutical industry, and managing subvisible particulates is a critical aspect of this commitment. Subvisible particulates, though tiny, can significantly impact patient health, potentially causing adverse reactions like inflammation or immune responses, and even compromising the efficacy of the drug. Consequently, it’s essential for drug manufacturers to conduct thorough subvisible particulate testing to confirm the safety of their products for patient use. 

Ensuring Injection Safety with USP 788

Subvisible particulate testing is an important aspect of drug development and manufacturing. These tests are designed to detect and quantify particles in pharmaceutical formulations that are too small to be seen with the naked eye, but could still cause harm. Subvisible particulate testing typically involves using specialized instruments and techniques like light obscuration, light microscopy and micro-flow imaging. By testing for subvisible particulates, manufacturers can ensure that their products meet regulatory requirements and are safe for patient use. These tests can also help identify potential issues with manufacturing processes or formulation, allowing manufacturers to make necessary adjustments and improve their products.

Gateway Analytical - Analysis Solutions

Defining Excellence in Injectable Drug Safety

USP 788 is a widely recognized standard for testing particulate matter in injections. It provides guidelines for testing the amount of particles in injections to ensure they meet certain safety standards. The standard outlines various tests and acceptance criteria for particulate matter in injections, including limit tests, light obscuration tests, and microscopic particle counting. These tests help ensure that injections are safe and effective for patients. 

Gateway Analytical

Ensuring Injection Safety with USP 788

Subvisible particulate testing is an important aspect of drug development and manufacturing. These tests are designed to detect and quantify particles in pharmaceutical formulations that are too small to be seen with the naked eye, but could still cause harm. Subvisible particulate testing typically involves using specialized instruments and techniques like light obscuration, light microscopy and micro-flow imaging. By testing for subvisible particulates, manufacturers can ensure that their products meet regulatory requirements and are safe for patient use. These tests can also help identify potential issues with manufacturing processes or formulation, allowing manufacturers to make necessary adjustments and improve their products.

Early-Phase Development

Comprehensive packages designed to navigate clinical & regulatory complexities of parenteral product-package and container-closure development, from concept to market readiness.

Container Closure
Integrity Testing

Quantitative, non-destructive, deterministic leak detection technologies for products stored in vials, syringes, cartridges, flexible containers, and bottles.

Particulate
Analysis

Multi-analytical methods to count, size, and characterize visible and subvisible particulate matter in pharmaceuticals, disposable containers, single-use systems, raw materials, and medical devices.

Medical Device
Analysis

Rigorous studies focused on enumerating particulate matter and identifying potential chemical compounds that could migrate from medical devices into the environment or directly impact patient health.

Extractables
& Leachables

Studies aimed at identifying potentially harmful compounds in manufacturing components and final containers to ensure the safety and efficacy of pharmaceutical products.

For comprehensive subvisible particulate testing services, turn to Gateway Analytical. Our advanced testing capabilities and expertise ensure that your pharmaceutical products meet the highest standards of safety and quality.