Lamellae and Visible and Subvisible Glass Particles 

Lamellae, along with visible and subvisible glass particles, refer to thin flakes or layers that can detach from the inner surface of glass containers used for storing pharmaceutical products. This phenomenon, often a result of glass delamination, can introduce contamination into the medication, posing risks to product integrity and patient safety. Identifying and analyzing these particles is crucial in maintaining the quality and efficacy of pharmaceuticals, ensuring that treatments remain safe for patient use. Gateway Analytical specializes in detecting and understanding the implications of such particles, utilizing advanced techniques to safeguard against potential contamination.

Ensuring Integrity, One Particle at a Time

The ‘lamellae and visible and subvisible glass particles’ test assesses the presence of lamellae and visible and subvisible glass particles in the solution. The analytical techniques to evaluate this parameter include visual inspection, stereomicroscopy, or scanning electron microscopy – energy-dispersive X-ray spectroscopy (SEM-EDS).

Gateway Analytical - Analysis Solutions

Gain Insight into Glass Lamellae and Particles in Solutions

At Gateway Analytical, we employ advanced techniques like SEM-EDS to identify any glass particulates, ensuring your packaging meets the highest scientific standards. Reach out to our experts for expert testing support. 

Gateway Analytical: Your Partner in Precision

Early data collection is key to identifying potential delamination incidents before they impact product integrity. For guidance on setting up baseline screenings or any inquiries about glass delamination, Gateway Analytical is here to assist. Contact us today for expert support in safeguarding your products.

Early-Phase Development

Comprehensive packages designed to navigate clinical & regulatory complexities of parenteral product-package and container-closure development, from concept to market readiness.

Container Closure
Integrity Testing

Quantitative, non-destructive, deterministic leak detection technologies for products stored in vials, syringes, cartridges, flexible containers, and bottles.

Particulate
Analysis

Multi-analytical methods to count, size, and characterize visible and subvisible particulate matter in pharmaceuticals, disposable containers, single-use systems, raw materials, and medical devices.

Medical Device
Analysis

Rigorous studies focused on enumerating particulate matter and identifying potential chemical compounds that could migrate from medical devices into the environment or directly impact patient health.

Extractables
& Leachables

Studies aimed at identifying potentially harmful compounds in manufacturing components and final containers to ensure the safety and efficacy of pharmaceutical products.

Covering every stage of the drug development journey with our state-of-the-art, FDA-inspected, cGMP-compliant facilities designed to minimize bottlenecks and maximize success.